Combinatorial Creativity: Or why modulation was the epochal event in Radiation Oncology

Martin Vial writing on Medium: There are three types of change that take place to create something new. First off, we can engage in combinatory change: adding new elements together to bring about something new. The example I used in an earlier article is the addition of the electric motor to a washbasin to create a washing machine. … Continue reading Combinatorial Creativity: Or why modulation was the epochal event in Radiation Oncology →

Prognostic factors in anal carcinoma- Role of p16 and tumour infiltrating lymphocytes (TIL)

This stimulating paper came from this tweet: https://twitter.com/achoud72/status/1440621536591839240?s=20 The PDF appears here: Wakeham, K., L. Murray, R. Muirhead, M. A. Hawkins, D. Sebag-Montefiore, S. Brown, L. Murphy, et al. 2021. “Multicentre Investigation of Prognostic Factors Incorporating p16 and Tumour Infiltrating Lymphocytes for Anal Cancer After Chemoradiotherapy.” Clinical Oncology 33 (10): 638–49. https://doi.org/10.1016/j.clon.2021.04.015. My summary of … Continue reading Prognostic factors in anal carcinoma- Role of p16 and tumour infiltrating lymphocytes (TIL) →

Effects of radiation on heart- A series of papers.

I stumbled on an interesting Twitter thread on effects of XRT on heart. They are mutlifactorial and no effective pharmacotherapy exists. Therefore, the onus is on the medical oncologists (to devise effective "less-cardiotoxic" therapies) and on radiation oncologists to devise effective delivery mechanisms without an obvious increase of the side effects. It is an exciting, … Continue reading Effects of radiation on heart- A series of papers. →

Radioablation for ventricular tachycardia

This paper was a recommendation from Prof. Soren Bentzen: https://twitter.com/SorenBentzen/status/1442557054200147968?s=20 The paper is linked here with the PDF here Zhang, David M., Rachita Navara, Tiankai Yin, Jeffrey Szymanski, Uri Goldsztejn, Camryn Kenkel, Adam Lang, et al. 2021. “Cardiac Radiotherapy Induces Electrical Conduction Reprogramming in the Absence of Transmural Fibrosis.” Nature Communications 12 (1): 5558. https://doi.org/10.1038/s41467-021-25730-0. … Continue reading Radioablation for ventricular tachycardia →