I somehow missed this important paper along with RADICALS RT. This paper is a meta-analysis of RCT’s for the timing of radiation- early salavge versus “progression”. The data is extremely heterogenous and there are many flaws in the supporting arguments. Nevertheless, I have included the paper as well as the summary. I hope you find it useful.
There was no evidence to suggest that the effect of adjuvant radiotherapy on event-free survival varied according to pre-surgical prostate-specific antigen, Gleason score, seminal vesicle involve ment, surgical margins, or CAPRA-S risk groupTweet
The usual disclaimers apply- submission was done anonymously. Only the word summary can be downloaded. The purpose of the blog is educational and I don’t have any commercial interest in either distribution of the content or it’s display (I don’t earn any revenue from the blog).[embeddoc url=”https://www.dropbox.com/s/0igvwatm57radoo/Sys%20Review%20XRT%20Prostate.pdf?dl=1″ download=”none” viewer=”google”] [embeddoc url=”https://atomic-temporary-167639548.wpcomstaging.com/wp-content/uploads/2021/01/Adjuvant_or_early_salvage_radiotherapy_for_the_treatment_of_localised_and_locally_advanced_prostate_cancer_a_prospectively_planned_systematic_review_and_meta_analysis_of_aggregate_d.docx” text=”Download Summary” viewer=”microsoft”]